芳基硫酸酯酶A
2020-03-23 11:09:06
1AUK, 1E1Z, 1E2S, 1E33, 1E3C, 1N2K, 1N2L, 2AIJ, 2AIK, 2HI8· cerebroside-sulfatase activity
· calcium ion binding· extracellular space
· lysosome
· endosome
· endoplasmic reticulum lumen
· integral component of membrane
· extrinsic component of external side of plasma membrane
· lysosomal lumen· glycosphingolipid metabolic process
· autophagy
· binding of sperm to zona pellucida
· central nervous system development
· response to nutrient
· response to pH
· response to estrogen
· post-translational protein modification
· cellular protein metabolic process
· small molecule metabolic process
· response to ethanol芳基硫酸酯酶A(Arylsulfatase A、ARSA、酰基硫酸酯酶A、脑苷硫酸酯酶/cerebroside-sulfatase、芳香基硫酸酯酶A)属于酶之一种,它可以分解脑硫脂(sulfatide),即分解"脑苷3硫酸"(cerebroside 3-sulfate)为脑苷脂及硫酸盐。在人类中,芳基硫酸酯酶A由ARSA基因编码。ARSA缺乏症与异染性脑白质退化症(MLD)有关,属常染色体隐性遗传疾病。芳基硫酸酯酶A被磷酸盐所抑制,从而与活性位点"3-甲酰甘氨酸"(3-formylglycine/3-oxoalanine)形成一个共价键。脂酶(胆盐依赖性脂酶、胃脂肪酶/舌脂肪酶、胰脂肪酶、溶酶体酸性脂肪酶、激素敏感性脂肪酶、内皮脂肪酶、肝脂肪酶、脂蛋白脂肪酶、单酰基甘油脂肪酶、二酰基甘油脂肪酶)磷脂酶(A1、A2、B)EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22
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2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9
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3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13
·Template:Glycolipid and sphingolipid metabolism enzymes(英语:Template:Glycolipid and sphingolipid metabolism enzymes)