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雄激素结合蛋白
2020-06-13 07:20:39

前列腺组织中含有丰富的雄激素和与之结合的蛋白,这些结合蛋白能够吸纳、浓聚性激素,因此将它们统称为性激素结合蛋白(sex hormone_binding globulin,SHBG).其中一种可以局部结合、凝聚高浓度的雄激素,即雄激素结合蛋白(androgen binding protein,ABP)。ABP是一种由睾丸支持细胞合成和分泌、与雄激素有高度亲和力的蛋白。

注意:此处包括了那些只有微弱男性化效应(或抗男性化(如氧雄龙))的蛋白同化甾类(因为它们合成代谢效应也是通过激活雄激素受体而是显得)。

Note: 21-Hydroxylase inhibitors may also affect androgen levels as they prevent metabolism of androgen steroid precursors.

Note: Though not listed here, many anabolic steroids can also be estrogenic as they can be aromatized into estrogen-like metabolites that possess estrogenic activity.

Note: Xenoestrogens (e.g., phytoestrogens and mycoestrogens) are not included here. For a full list of xenoestrogens, see here.

Note: 5α-reductase and 21-hydroxylase inhibitors may also affect estrogen levels as they prevent metabolism of estrogen steroid precursors.

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